I have had both in Encore barrels, I like them both, but went to the Revolver for my hunting needs and wants.
I think the 460 offers the ability to shoot a smaller bullet very fast, and the 45-70 offers the ability to use a lot bigger bullets if you decide to go that route.
If I had to pick one, it would be in a Encore handgun, I would go with the 460 Mag.