I'm going to open a bucket of worms here. But think about this realistically. I know we all have our favorite calibers to hunt deer with in our Handi Rifles. But some of the calibers are not true calibers for hunting big game. Some are marginal at best. But say you are going to visit someone and they would take you on a hunt of a life time, what caliber would you use.
Whitetail? 30-30
Blacktail? 25-06
Mulie? 30-06
Elk? 30-06
Antalope? .270
Black Bear? .35 Whelen/30-06
Grizzly? 45-70/450
Moose? .35 Whelen/30-06
Caribou? .270/30-06
All these animals are with in driving distance of each and every one of you. Think about this real close. Would your .243 be up to it?
Frank Glasser used a 22-250 for Caribou, Moose, and Grizzly. But Frank Glasser was an old time expert on game anatomy, on shooting, and hunting. I listed my choices, what would yours be?
Then Let's agree to disagree.