I know this is one step down on the caliber, but I am in the process of selling my Walther ppk and I am buying the Smith 386 Mountain Lite. (So at the end of a hard day's hunt, I can have a Bud lite and all will be good with the world

).
But seriously, When I predator hunt, I use a single shot rifle and I carry my Smith 44 mag 629 4" as a side piece. It's my "blankie". The only problem is after about 3 or 4 hours it keeps pullin my pants down. So....enter a lighter gun with enough punch to keep me happy.
I handload, so to keep the gun managable on the recoil side for target shootin, I'll just load some lighter 357 loads. I'm not much of a fan for shootin 38's out of a 357 so I won't go that route.
Currently for my 44 mag, I load light rounds with lead flat nose bullets for just going to the range and shootin at 25 or 50 yards. It's a bunch of fun and you can shoot 50 or even 100 rounds in an evening and not have to see a surgeon afterwards.
Then I load up the "big boys", practice three or four speed clips with those to see how and where they hit and call it a day. Then when I go out to the woods, I load up the power house ones. (for the 44 it's usually Vihtavouri and 200 grain Hornady's...these will certanily get your attention....and anyone else within 200 yards)

Dave.