In my opinion, there are a lot more diverse cartridges to use for 'Whisper' type chamberings. For instance....what first comes to mind is the 7.62x39. I have owned a JDJ Whisper before. I traded it for something else, then I got a NEF in 7.62x39 for 'Whisper' experiments. My SKS with light loads and large cast bullets was a lot quieter than the SSK offering. The difference with using the 221 brass or 7.62x39 is that you can also load them 'hot' and have something realistic for hunting purposes. The 300 Whisper is fine on deer if you can always get a 20 yrd shot. Other than that...about the only thing I can see a use for a 300/221 is for shooting people..... Humans are the only animal that will 'give up' and cry if maimed and injured. Deer will not, they will run away, and to use something that does not have any 'knockdown' power in my opinion is not a humane kill..