Matt,
Proper seating is what many of us mentioned to you right off. Its a COMMON, problem when one has misfire issues.
I really dislike any manufactures priming setup that allows you to seat a primer by "feel". Its far too subjective. With all the compound leverage available in most primers, "feel" just is too inconsistent. Lee, Lyman, RCBS and foster all make a press mounted priming die setup. Your set up the die in the top of a single stage press so that when the handle is down at its lowest point, the ram its at its top. Seating the primer EXACTLY the same every single time. Its not expensive, its a much better system and along with cleaning, uniforming primer pockets and deburring flash holes, will allow you to make better, more consistent ammunition.
What does a correctly seated primer look like? Lyman recommends a small piece of glass be kept on your bench next to the priming station. After seating a primer, place the base on the glass and it should sit dead flat and rock steady. The primer will be just below flush but not be flattened or have its shape altered at all. Now this is also one place where you CAN feel a primer and its OK as its only using your finger tip. Press your finger on the primer. You will feel how its ever-so slightly below flush, that's a properly seated primer. If you have uniformed your primer pockets, like I mentioned, every single case will be exactly as the others.
Good luck,
CW