Yes, you need a slower powder to get the most out of it. A faster burning powder may get you fast speeds in a short tube, but your slug may loose speed by the time it exits if pressures drop too far off.
I'm pushing 250-265gr slugs close to 2800fps and 300gr slugs to about 2500fps with a 32" BC barrel. Pressures are in the upper levergun area. I dont shoot anything heavier than some experimental 325gr slugs, the vast majority are 300gr'rs or 300gr'rs drilled out to 250 +/- grs.
...slow/medium burning powder, lots of of it.