Old Schoolr - With all due respect, most owners of Pythons never know their revolver is out of time because it doesn't spit at them, it spits at the guy shooting next to you. Just for the heck of it, next time you are shooting your Python at the range, put a piece of cardboard about 8x10 about twelve inches on either side of your revolver, being sure to position at the barrel-cylinder gap and see if you get any stuff on the cardboard. Lead bullets would be worse the jacketed, but I've seen them spit jacket pieces as well. I don't know about Pythons, but with Smiths, if you get too far out of time, you can crack the forcing cone.
Hammerhead - You may be right about Colt lockup, but I would think Smiths and especially Rugers would lock up tighter. Sure, a Colt rotates towards the frame so that pushes the cylinder inwards, but Colt does not have a front retention device. Smith does and Ruger with their crane-lock system is even better even though they rotate outwards from the cylinder.That's my two cents on that.
I think a Python is the most beautiful double action revolver made and probably the smoothest action from the box. I'm not sure who wins after tune-up, Smith or Colt, but both should be smooooth. My main problem with Colts over the last several years is that they were extremebly pricely for what they were and I don't think they were worth the premium. I think for the dollars invested, Smiths are the very best investment you can make. Amen to the 6" model 27 mentioned above. Now THAT'S a premium revolver!!They are beautiful as well.
I just recently purchased a Colt Trooper Mark III that had been tuned and it is really smooth and has a great single-action trigger, however the double-action is still pretty heavy. The leaf springs on the Python and Smiths are sooo much better.