I was able to take a doe deer today with my new, to me (I bought it used) FA 454Casull. The deer was ranged at 62 yards. Shot where I was aiming which was the heart. It was about 15 minutes until sunset and I did not want to track her in the dark. I thought about the neck but even the mature doe in my part of Texas have skinny necks. I was a little lower than necessary , but hit the bottom of the heart. This was a handload of 29 gr H110 CCI 450 with 300 gr Hornady bullet, a little overkill. Bullet passed through, deer ran about 15 yards and dropped. This is a 7 1/2" field grade with a Burris 2X7 scope. This gun and load will shoot one expanding hole at 50 yards. I am impressed with this handgun.