Mornin Dinny,
To my mind its a perfect opportunity for a Shotgun/Handgun combo! I have done this myself many times, but I go Rifle/Pistol. My CF rifle, is usually my 25 or 32-20 and my G23. The pistol being my close range/defensive gun and the rifle longer or precise shots.
Another thought but brings you away form Handis, but is using a H&R Cousin the Savage 24. Its a PERFECT combo gun in a shotgun /Rifle in many flavors. A 22M/20 would be nice a 357/12Ga if you could find one the "Turkey special" 223/12Ga in camo would also the "bomb"...
But your 45Colt WILL BE FINE! I hve shot a couple pigs with my own Bisley 45COLT. Not a single complaint!

Properly loaded, with a good accomplished and experienced shooter there is not a critter walking you could not put in the freezer.
Buck shot, from a rifle sited barrel within the ranges your talking (Shot like a rifle) will dispatch the biggest hog! I am not a fan of buck shot used like bird shot, its a great wounder, but shot like its a single projectile, from a barrel that patterns it well, with in proper distances, its devastating. #4 magnums are my favorite.
CW