Obviously, lots of cartridges will do, and those listed above are an example of that fact. Many are more powerful than necessary for whitetails. If a person has to ask this question, they probably don't need anything too exotic. The .44 Magnum will kill any subspecies of deer that ever lived with power to spare, ammo and components are readily available, recoil will be tolerable in an Encore, and the accuracy will be more than what's required. KISS principle.