I have not killed a deer with the 225 grain red tipped bullets yet, but I normally hunt with the Hornady 200 grain XTP over a full charge of VV N-110. My Smith M-29 PC revolver will put all 6 shots in a 6" pie plate (even after I've eaten the pie

) at 100 yards. (from a bench of course).
Now, the M-29 will do the same thing with the same POA using the 225 grain red nose Hornady's.
I find that pretty impressive since the red nose bullets are 25 grains heavier. Same POA, same POI, heavier bullet @ 100 yards.
FWIW
Dave