I been using the 41 since it came out. originally a blackhawk, than to a redhawk and a 14"tc. I'm using H110 with the 220 sierra silhouette bullet for hogs and elk, and the 210 and 170 for deer. With good shoot placement, the tc extends the range to 150-175 yds. The red hawk w/ 2x scope to 125, 75-100 ironsighted.
I use cast bullets for messing around but prefer the sierras for hunting. Nothing has run more than 30 yds, The only bullet recovered was a 210 out of the tc at 205 measured yds, head on into the chest. We found it under the skin after going the complete length of the body. Witness said it just stood there like- "I'm dead, now what do I do" and collapsed in a heap with a thud he could hear 100 yds away.
I wouldn't use it for for moose at all or elk or bear over 75 yds but for deer it's perfect. Less recoil, lighter weight and I doubt any deer knows the difference between the 41 and 44. Some will say that the bullet selection is poor but if you can't do it with the available bullets, You shouldn't be doing it!!