While I have never played with the .17 Fireball, I do have a .17 Re. a .17-223 and a .17 AH. The .17 Fireball should have no problem with a coyote, with a good bullet, a 25 or 30 gn. Berger and not the MEF`s. Calhoon bullets also a real tough, if your gun will shoot them. I shoot the 19 gn. Calhoons in my .17 AH and believe they would be a good coyote round to 150 yrds. or so.