I shoot the Remington Premier, sighted 3" high at 50 yards.  I hold on hair to 125 without adjustment.  I have tried these at 200 yards, and found about 13" drop at that range.  I hunt an area where only slug guns are legal, and there are some wide open places.  Based on my practice, I would not try these much beyond 125.  In a really good overall situation, I might try 150 max.
 
Ben