I've got a couple of boxes of Barne's 250gr bullets. That is what the wife was using when she shot a Grizzly that was coming in to take a Moose away from us.
My pet loads for the Handi's are: Factory Remington 150 and 180gr Corelokt. Speer 125gr TNTs in front of 51gr 748. Sierra 165gr SPBT in front of 58.5gr of IMR-4350. Nosler 165gr Accubond in front of 61.5gr of RL-22. Nosler 180gr Partition in front of 58gr RL-22.
I liked that Sierra 165gr boat tail, and have used it for years, but since Nosler came out with the Accubond I am leaning more towards it, with RL-22. Higher velocity, and good accuracy. I'm getting better bullet performance with the Accubond at longer ranges.