Try taking out the locking lugs and give them a good polishing with a stone or fine sandpaper, just in case the lugs are not slipping into the frame securly. This can be a problem more often than you would think. See the sticky about fitting an old barrel to a G2 frame.
As far as the headspace...
If the chamber is a little too short, even a couple of thousandths, the case will sit too far out of the chamber. When the hammer strikes, the case will be driven forward into the chamber, thus causing a misfire. This can also be caused by the shoulder of the case being too far forward. The forward movement is causing a "cushioning" effect. This can even happen with factory ammo - factory ammo has been known to be less than perfect.
Try firmly closing the gun, open it then firmly close it again. This may crush the cartridge into the chamber and allow the gun to fully lock up. Worth a try. I'm still betting on the locking lugs.
Wouldn't hurt to install a heavy locking bolt spring and a heavy hammer spring. I installed both and misfires are a thing of the past.