30-06, Oh, Oh, Oh, good choice! With a 165gr bullet in front of Reloader-22 you will be good for Coyotes, Hogs, and Deer. Even Antalope if you live or go out west. With the 180gr you will be set up for Elk, Moose, or Bears. 110 to 125gr works well for ground hogs, problem is they explode. Nothing but solids work for Foxes, then don't hit a major bone. Foxes are just too delicate for the 06, they get messy.