By size, do you mean diameter that you can chamber? If so, you'll have to do a chamber cast to determine that, I've loaded .460" bullets with no problems. Length is another matter, most H&R 45-70s have short throats, but not all, so you'll have to just try the bullet you want to load to see how deep it needs to be seated, different ogive contours will change seating depth. There are several bullet mfrs that make heavy bore rider bullets that are designed for short throated barrels, the front part of the bullet is smaller in diameter to actually enter the bore beyond where the rifling starts when the round is chambered.
Tim