I'm a believer in Hornadys XTPs.  I've shot half a dozen or more deer with the 44 mag, using the 240 XTP and W296...had good results on all.  Two years ago , I lost a nice buck to my 44 Encore...I was using a 240 Nosler HP.  Maybe the shot placement , maybe not....I'll never know.  I'm using Hornadys again.  I have yet to try the 45s on deer.  Good luck.  BTW my 44 mag load is pushing around 1350 + FPS from my 7 1/2 inch Blackhawk.
regards , irold