Matt, I use .38s in both my 2 Handis (.357 and Max) and Blackhawk for getting rid of red squirrels. I kinda blows em up, but I don't eat reds. Head shots on grays and fox would be fine. Both Handis are deadly accurate The .357 is redundant now that I reamed the other to Maximum, so I may ream it to .35 Remington or swap it for a 1~9 .223 extractor.
Ronp, The .357 is less than the .30-30 on deer. Get the .357, ream it to Maximum, and you've got it all.
Pete