Hard cast bullets can be driven up to 1,000 fps without appreciable leading. Over 1,000 fps, and you should plan on lots of bore and chamber scrubbing, or reduced accuracy. If you want to go faster than 1,000 fps, I highly recommend some jacketed bullets.
Check your loading manual and try a few loads that lead up to 1,000 fps. Load a dozen or so in 1/10th grain or so increments up to the maximum load, mark them differently and take them out and try them. Take a pad and paper and keep notes. Look for leading, fouling, primer flattening, overly extreme recoil, or any other signs of trouble. If you see any of these...back off. Watch the accuracy, also. Lots of times your most accurate load is not necessarily the hottest one.
Unique is a great powder...but a little dirty. I prefer Clays or (my favorite) Bullseye.