I would use 55 gr Remington factory i have never shot a deer with the 55 gr Remington but it shoots good in my gun but might look at a different cal for deer like the 25-06 ,243 7mm-08 and the 6 mm i have used the 25-06 and works good the 22-250 will work for deer but is lite for deer but under 100 yards and a good shoot well work and even 2 in. will work at a 100 yards mark