For black powder there's a definite advantage, but even with smokeless powder, the larger case keeps pressures down, although there isn't any data over about 30kpsi for the 45-90 or bigger, a 45-120 shooting a 500gr bullet with 60gr of H4895 will push it well over 1800fps in my BC at <30kpsi, but in a 45-70, if you throated it, you could do the same thing, but at considerably higher pressure, well into the Ruger levels. Look back a few pages, there are several threads on the 45-90 and bigger rechambers. Throating info can be found in the FAQs along with a reamer rental source if you haven't seen it yet.
Tim