If moose/elk is potentially on the menu, I personally would go with one of the following 4 calibers: 300 Weatherby or 300 Remington Ultra (not short-action) Mag with a 180 or higher grain bullet, 340 Weatherby, or 375 H&H.
If you really need 400 yard reach, leave the 375 H&H off the list as hitting anything past 300 yds would be dicey with this cartridge.
Why the heavies (340 &375) ?
Elk can be extremely hearty and often are not that easy to drop...most authorities say Moose go down easier.
All of these cartridges recoil a HEAP more than a 30/06, so beware; I happen to be fairly insensitive to recoil, but I know others that think a 300 Win Mag kicks like a proverbial mule....most shooters can learn to accurately shoot up to the 375 H&H mag with PRACTICE.
Next year I plan to deer hunt in Michigan with my new CZ550 458 Lott...too much gun ? Yep, but I doubt the deer will get up complainin' that I over-gunned him.
By the way, I would not EVEN CONSIDER using the 25/06 on such large game...the light bullets used in this caliber are just not up to the task & even if they were they make a VERY small hole relative to the size of the game animal (Elk/Moose). The 25/06 is a great DEER cartridge, but would most likely do a great deal more to WOUND rather than drop Elk/Moose.
Craig Boddington does not see any caliber 270 and under as a reasonable selection for game Elk-size & larger.