If you are looking for a gun with 22 hornet ballistics, it is a better choice than the hornet because of the better brass. I personally like it in my 10" barrelled Contender handgun. In a rifle, I'd get a 223 instead because it's more versatile. Starting loads with good accuracy (for varmint hunting) with the 223 are about the same as hornet loads or 221 loads. Mine was very finicky about loading components. It took several experiments to finally find a combination that got me to 1" groups at 100 yards. 2.5 inch groups were easy. But remember, I'm talking about a handgun.
If you do get one, use IMR 4198 powder to start with. Also try the Speer TNT bullets.
Also be sure to get one with a 1:10" twist. My barrel is 1:14 and will not stabilize any of the plastic tipped bullets.