Hmmmm. I"ve killed over 50 deer in my life. 22 of them with the NEF 45/70, 18 with a 6mm Ruger #1, 3 with a 8 x 57(hot loaded), and a few more each with 30-30's and 30-40 Krags. An' a couple of other's where I'd rather not mention the caliber. Longest shot was 125 yds. Don't forget,uh, some of us Live and Hunt in THE WOODSSSSSS. Any of the calibers mentioned in such a disparaging way will kill deer at reasonable ranges, but granted if your going WAY OUT THERE, then the '06 or any of it's fatter or skinnier bretheren are the way to go.