My only experience is with the 44 Mag, in 2 Ruger Super Blackhawks, a Winchester M94, a Ruger 44 Carbine and a S&W M29 6.5" revolver. I can, from over 40 yrs. experience in reloading/hunting/ and target shooting with this caliber, and taking many cleanly killed game animals-I like the 44 Mag. I have taken somethings with 45 rds,-45ACP, very cleanly, but when you get into he 45 cal class-so many more effective upgrades come into play that the 45 Colt is degraded to a 38 Special wadcutter status. There some good loads, but seem to be a waste of time, to only biut a purist-good luck.