In my reloading room, certain powders, no matter the bullet weight or charge, get a magnum primer. 2400 is one of them. In addition, I use a heavy roll crimp with jacketed bullets, and all the crimp I can get away with with cast or swaged and that powder.
I get good, consistent, shot to shot performance with all bullet weights, from 110-160 gr., especially in revolvers, with that combination. It's true that you don't "need" a crimp in a single shot rifle, but I think you'd see the difference when you put the loads over a chronograph.