While I use my rimfires much more than my centerfires, I'll still keep my centerfires..
1) While there are 2 reservations in my county, I don't live on either of them, so my 30/30 is for deer/bear..
2) Varmint hunting, primarily woodchucks, are my forte. Most often I use a rimfire..but in large fields where my .22 mag or .17 HMR poops out...I may want to go to my .223 or .243..same goes for predators.