I don't use a holo or red dot on a hand gun at this time but have used them quite a bit over the last 8 years or so on .223/5.56 through .45-70 carbines. Any quality (Bushnell, Burris, Aim Point, EOTECH...) and even some of the cheaper holo or red dot will hold up indefinitely to a .243 in a TC Encore hand gun.
You will find, as you have already observed, quicker target aquisition but you will find that with low light conditions (last half hour of legal shooting light) you will have difficulty identifying the target and they don't work worth a flip using a spotlight on varmints/predators after dark. Don't expect to shoot tiny groups anymore, especially over 100 yd; expect your groups to be in 2"-3" range at 100 yd and around 2X that at 200 yd if shooting that far.
I have found that a 6 O'clock zero lets me shoot a tighter group. I stack the X-ring on top of my sight's red dot for an "8" sight picture and zero so that my impact is high enough at a 100 yd to impact the X-ring center and even with .45-70 and .45 Colt heavy loads I can shoot minute of deer at 200 yd with a high center chest hold.
Hope this gives you a little more information for your decision making.
v/r
SH.45