Off center pin strikes are very common, don't worry about it as long as they fire, I have several H&Rs that have very off center pin strikes and they shoot excellent. The easiest way to check the chamber itself is to drop a factory round in the chamber(remove the ejector first if it's not an extractor) it should be flush with the chamber face, not recessed, any recess adds to headspace, it doesn't take too much to cause misfires if firing pin travel is minimal.
You should have .040"-.060" pin exposure after dropping the hammer slowly while holding the trigger back to keep the transfer bar up, measure it with the tail of your caliper.
Tim