There have been several people that have done just that, reamed a 22 Mag barrel to some center fire. Larry has mentioned he has done several I know that Richard (Stimpylu32) has done at least one to a 218 bee and I think maybe one or two others. Keep in mind that not only is the steel milder, it has a twist rate of 1-16" so you are going to have to use lighter weight bullets so they stabilize. You will also have to fit your barrel to your frame. I think I am capable of doing this, but I just have not done it. All my barrels have been factory fitted. I do not think that there would be an issue with it blowing up, unless the case was loaded up beyond safe levels. It could be a bomb - but it could be in a 4140 steel barrel too. It has been debated here before. You might consider sending in your frame to have a 22 Hornet barrel fitted and then ream it to what ever. You will get a 1-12" twist rate barrel with 4140 steel and be factory fitted. Good Luck and Good Shooting.