Yeah, Tallwalker, the 22-243 is one of those "oldies, but goodies, from the musty, rusty, dusty file"...not many still around that know about it. Everyone is all Jones'n for the 22-250 AI. The Ruger was a SS "all weather" with their lightweight barrel...close to a #1 contour, and that UGLY squashed in stock. I had to send it back to Ruger to be restocked and a new barrel installed.
The original throat was way wrong, I couldn't get ANY bullet to touch the lands and still be in the case, and I was lucky to get a 3 shot group to stay below 2". The re-vamped rifle shot 1" and less....mostly much less....with 40 gr VMax.
That Ruger became a "switch barrel" and has a 7mm-08 on it right now, plus 308 and 260 barrels and is in one of Richards Gunstocks early laminated and modified "wildcat" stocks.
My first Midd was a rechambered Ruger Tang 220 Swift 1-14. It shot 1" with just about any weight bullet...just like the original chamber. Wouldn't get any smaller no matter what I did...and I did everything I knew and a bunch of old timers suggestions. The second was a rechambers 22-250 Ruger barrel...did the same thing...the third was a 26" Douglas premium air gauged 1-12 straight taper #7 and it stayed around 1/2 most of the time with just about any bullet but would do bugholes if I spent a lot of time on prepping the ammo. This last one is a 1-10 twist and does 3/4" with the heavier bullets and 1" or less with the 40 gr VMax and does XXXX...I won't even post the velo because no one will believe it...I don't sometimes. I still shoot high a few times before I get situated especially after shooting rifles in the 2800-3200 f/s range for a while.
The Midd works fantastic out to about 300-350 yds...maybe a little farther...with the 40 gr, but drops of so fast after that it is hard to hit anything. I keep about 10 rounds of 60-70 gr Hornady, Nosler, or Sierras loaded for those 400 plus shots and swap around between it, the 243 and the larger cals for out around 600 yds...I don't have much success much beyond that off a PU, even using a bench. Make'um jump tho' and have a hard time shooting more than a couple because I'm laughing so hard at them running over each other.

hahahahahahah
Anyway...I keep pushing the Midd for the advanced reloader or someone wanting a rechamber, but the 22-250 is probably a better choice since ammo is readily available and I don't recommend wildcatting for anyone but the hardcore reloaders.