the 22-250 is fun. It really "barks" when you shoot it. Last week I had someone ask "what the heck you shooting over there, that things is loud". I answered "just a little old .22"
I have found that hand loads start to show "stop here" pressure signs around 1 grain below max in the Hodgons books. I been shooting 55 grain boat tails (that come in the bulk Winchester bags) Never could get the clover leaf groups at 100 meters so this last bag I bought was 50 grains, some kind of hollow point I think. I was looking for 40-45 grainers but they were out of the bulk stuff.
It is neat where I can be sighted at 200 meters, then turn around and hit the ram at 500 meters without changing the scope

2 weeks ago my buddy brought a silhouette he had built out of 1/4" AR plate. At 200 Meters the 22-250 was just about going through it. Some of the holes you could see light through!