Yes - about 99% of all reloads from 100 - 1000yds. The degree of fouling using any brand of powder is contigent on the relative humidity and temperature. Black powder is hygroscopic.
At long range, accuracy will decrease if one doesn't blow tube or patch wipe after every shot.
Bill, I did a test one day- low RH and hot: 20 rounds - starting @600yds with no wiping or blow tubing. After the 3rd shot on target, the bullets moved off the 600yd paper and started dropping down and hitting the 400yd berm