Mike357
You will find that the damage that the 375 H&H does to a deer is very little. At my family's slaughterhouse, we would process many deer every year during the fall and I have witnessed the damage from about every popular caliber out there. There was a big game hunter who used his 375 H&H and it would be a small hole going in and a small hole going out, and they always dropped. Meat loss was very small and much less than most of the small caliber magnums and high velocity rifles would do.
I owned a Ruger #1 375 H&H for many years and killed two does with it during anterless season. I had used the Remington Factory 270 grain soft points on them, but never got one with the handloads then. I regret selling it before moving to Virginia, and have recently purchased the new 375 H&H barrel for the Encore. I would warn anyone that recoil is very stiff with the 375 H&H, but I found it less sharp than a 338 WinMag or 300 Weatherby with heavy bullets. More of a VERY hard push than a mule kick. I still want to make that trip for Moose, Reindeer, and/or Elk, just never got the time, and that is why I had sold it.
If you shoot short distances, the 375 H&H allows for reduced loads with SR 4759 (Hornady and Sierra manuals) and the flat nose bullets designed for the 375 Winchester. They won't have the long range ballistics, but are light in recoil and a great woods gun. They do mimic the velocity range and stopping power of the 375 winchester. I would suggest them for any range shooting. Start out on the light end for the magnum loads and use bullets in the 270 grain range when beginning shooting the heavy stuff. You will find that the H&H is pretty accurate across many different loads, and you need to find one that is comfortable. I used to shoot mine from a standing shooting monopod at the range since the full-house loads were too much for setting at the bench.
Rich C.