I own a 300 RUM and was on the verge of going Weatherby for a few reasons.
1, the rifles chambered in 300 Wby - I prefer the Vanguard's extractor system.
2, the price of 300 RUM skyrocketed to $45 a box, I remember getting if for $27. I cannot find it for less than $40 online, to which one must add other costs. I can get Weatherby brand 300 Wby ammo for $35 a box.
3, the Weatherby round, due to its case shape, is slicker feeding and more efficient that the 300 RUM. The advantage of the 300 RUM is its case shape can provide for extreme accuracy at long ranges, but it would be a tall order to beat the quality of Weatherby ammo.
I am strongly leaning towards the 300 Win mag, however, for a few reasons.
1, Much greater variety in ammo and rifle choice. I can't name a rifle made in 300 Wby or 300 RUM that isn't also made in 300 Win mag. Can also get rifles in this round not available in the others, such as the Rem 700 DM. With the action length of the 30-06, many rifle, stock, and accessory options are available that aren't for the higher magnums.
2, Hornady heavy magnum ammo is the same price as the lowest 300 Wby ammo and ballistically similar. I could run a steady diet of this for the same price of 300 Wby if I wanted, but would most likely use it only on occasion, and stick to $20 a box ammo more regularly. Match ammo is also available.
3, Certain bullets designed for the 30-06 just barely hold together at 300 Win Mag velocities but blow apart at 300 Wby velocities.