22-250 is a great round,as is the 223 thats why I have both.I agree with Rowdy and bigjeepman,don;t let that 223 go,you will regret it later.To good of a shooter.Now if you want a 22-250 for longer shots,get another handi or even a barrel,then you are good to go!
Can't help you as to factory ammo as I handload only.With good loads I can't tell any difference between the two as they both are under half inch groups at 100 yards.But don't get rid of that 223.unless you sell it to me!