The screw that you are referring to is the strain screw. It should be very snug, not just tight. It preloads the hammer spring, and is vital to proper ignition. Put a bit of tourqe on it, when you tighten it. If that doesn't fix your problem, then take a look at the firing pin. If it's fully intact, try various loads. If the problem persists, send it back to S&W. Their customer service is great, and they will make it right, most likely at no expense to you.